The Case: 

• Pam is dealing with brain fog, poor concentration, and fatigue.
• Tests revealed that she was low in Folate and Vitamin B12.
• Weeks of taking Vitamin B Complex didn’t help her symptoms at all.

A little more research helped Pam understand that not all B vitamins are the same - some are synthetic while other options are natural and in methylated forms. Inspecting the B Complex vitamin she’d been taking, she discovered that the B12 was in the cyanocobalamin form and the folic acid was also synthetic.

You might think the mystery was solved at this point, but after finding a methylated B Complex at the local health food store, and taking it for several weeks, her symptoms persisted. She increased her dosage, but after several weeks, she felt even worse. 

Her labs showed that she was deficient in B vitamins, so why weren’t her supplements working?

The Investigation

This is something I commonly see and while B vitamins are wonderful, they come in many forms but they are not ‘one size fits all.’

And there is another misconception - people believe that because B vitamins are water soluble, they can’t hurt anyone because the body will expel what it doesn’t use. This isn’t the whole story. 

How Methylation Works

The body has a process called methylation. This is a biochemical process where there is a transfer of four atoms - one carbon atom and three hydrogen atoms (CH3) from one substance to another.

This process happens all the time, every second. When its optimal it has a significant positive impact on many biochemical reactions in the body that regulate all types of activities. Methylation is needed for neurotransmitter production, detoxification, histamine metabolism, estrogen metabolism, fat metabolism, cellular energy, eye health, and immune balancing.

Essentially, if you think of the body as a machine, then methylation (and demethylation) are the gears that trigger the different systems in the body. 

Two important methyl donors (nutrients that keep methylation moving) are methylated folate (also known as methyltetrahydrofolate or 5 MTHF) and methylcobalamin (methylated B12).

It’s worth noting that there is a gene called the MTHFR gene (which we’ve talked about in Episode 34) which makes it harder to convert folic acid from foods or supplements into active form. 

Understanding the Role of the MTHFR Gene in Methylation

The process of methylation is quite complex. We have about 30 enzymes that are part of the methylation cycle pathway. The MTHFR gene is only one piece of the puzzle. And, while the MTHFR being off can cause issues with methylation, those other enzymes can also be a factor (sometimes a major factor).

Balancing Methylation

You may have heard that methylation is all about taking methyl folate or methyl B12 but there is so much more to it. 

Think of methylation (and methyl donors, specifically) as a bell shaped curve. You want to be somewhere at the top of the curve to be in balance.

If you are lower on the left side of the curve, that is considered less methylation or being an under methylator. If you are lower on the right side of the curve, that would be considered too much methylation or being an over methylator. So many doctors don’t realize this and think more is better. More is not always better, balanced is what you want to aim for.

Symptoms of Unbalanced Methylation

When you are not in balance (in either over methylation or under methylation) you can experience symptoms. And, taking more B vitamins (especially the wrong kind) may make things worse - even if you’re taking methyl folate and methyl B12 (considered to be the best). There are tons of issues with sub optimal methylation and some can actually be the same when you are an over or an under methylator

• Anxiety
• Itchy skin
• Brain fog
• Mood changes
• Fatigue
• Jitteriness
• Allergies
• Immune challenges
• Environmental sensitivities 
• And many more…

How to know if you are an over or an under methylator?

Looking at genetics can help but genetics don’t actually show what is expressing and how it's affecting metabolism itself. I like to look at specific biomarkers to see what the body is doing rather than just looking at the genetics which can be a bit deceiving. For example, someone with MTHFR may not actually need more methyl folate.

The good news is that there is a simple blood test. It's called the Histamine Determination Whole Blood Test. This lab test can be done at Labcorp. It is really helpful in determining if you are an under or over methylator. If the level is high, you are an under-methylator. If it’s low, you’re an over-methylator. This test is done at many labs but from everything that I have learned about it, it's something that is only accurate at Labcorp and needs to be sent there.

As with most tests, there is a lab range and an optimal range.I made a handout on how you can check your methylation status. Please  CLICK HERE to access this handout where I give the exact LabCorp test number so you can easily order or ask your doctor to order the test along with the optimal ranges. Based on those results, I detail which B Vitamins would be best for you. 

Supporting Overmethylation and Under-methylation

Once you find out your levels, if you are an under-methylator, take more methyl donors such as:

• Methylated Folate
• Methylcobalamin

If you are an over-methylator, take less methyl donors and look for ingredients such as:

• Folinic acid
• Hydroxocobalamin
• Adenosylcobalamin

Mystery Solved

If you are taking B vitamins and feel off, perhaps you are not taking the right ones. This can also happen with multivitamins. If you feel upregulated or like there is something under your skin that may be a sign of being over methylated. If you are very sensitive to chemicals, while there can be many things related here, methylation also plays a large role so please take a look at this.

This was the case for Pam. We ran her labs and she was very low indicating that she is an over-methylator. We changed her B vitamins and she felt a huge difference in her energy and brain fog.

Eliminating Health Mysteries

For Pam we were able to find that missing piece of the health puzzle and help her regain her health. Could methylation be the missing clue for you or someone in your life? 

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