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Answers from the Lab
Trailer
Bonus
Episode 125
Season 1
Stiff-Person/PERM Evaluation: Andrew McKeon, M.B., B.Ch., M.D.
(0:32):
Before we get started, Dr. McKeon, could you please tell our listeners a little bit about yourself and your background?
(01:13)
How long have you been with the lab?
Before we get started, Dr. McKeon, could you please tell our listeners a little bit about yourself and your background?
(01:13)
How long have you been with the lab?
(01:37)
Could you describe which patients should have this testing and when should it be performed?
Could you describe which patients should have this testing and when should it be performed?
(01:50)
Can you tell us a little bit about this unique assay that has not only glycine receptor but also other antibody tests?
(03:12)
We offer this evaluation in both serum and CSF. Can you offer any guidance about when one is more appropriate than the other?
Can you tell us a little bit about this unique assay that has not only glycine receptor but also other antibody tests?
(03:12)
We offer this evaluation in both serum and CSF. Can you offer any guidance about when one is more appropriate than the other?
(04:37)
Four different antibodies are included in the stiff-person assay. Why is it most appropriate to evaluate all four? And why is this assay separate from our movement disorder evaluation that includes 20 different antibodies?
Four different antibodies are included in the stiff-person assay. Why is it most appropriate to evaluate all four? And why is this assay separate from our movement disorder evaluation that includes 20 different antibodies?
(06:19)
Is it important to include all relevant antibodies — but not those would lead physicians down a confusing path?
Is it important to include all relevant antibodies — but not those would lead physicians down a confusing path?
(07:50)
Can you give our listeners a couple examples of patient presentations that might lead a physician to order this evaluation, and a couple examples where it wouldn't be appropriate?
Can you give our listeners a couple examples of patient presentations that might lead a physician to order this evaluation, and a couple examples where it wouldn't be appropriate?
(09:59)
Can you give a couple examples of when a broader movement disorder evaluation would be appropriate?
Can you give a couple examples of when a broader movement disorder evaluation would be appropriate?
(11:11)
How does this new stiff-person evaluation improve upon previous approaches? What will this new test offer to physicians?
How does this new stiff-person evaluation improve upon previous approaches? What will this new test offer to physicians?
(12:35)
What does a positive or negative stiff-person evaluation result mean for a patient's care?
What does a positive or negative stiff-person evaluation result mean for a patient's care?
(13:25)
How do alanine receptor positivity and immune responsiveness affect a patient's prognosis?
How do alanine receptor positivity and immune responsiveness affect a patient's prognosis?
(13:58)
Can tests other than this offering from Mayo Clinic Laboratories give physicians the same answers?
Can tests other than this offering from Mayo Clinic Laboratories give physicians the same answers?
(14:44)
What is the key takeaway about this test?
What is the key takeaway about this test?