The article "Stem Cells for Musculoskeletal Conditions: Hope or Hype?" from Dynamic Chiropractic explores the current state of stem cell therapies for musculoskeletal diseases. While human stem cells possess remarkable potential for regenerative medicine, the article highlights a critical lack of rigorous scientific evidence supporting the effectiveness and safety of treatments offered by commercial stem cell clinics using minimally manipulated adult-sourced cells. For conditions like disc pain, tendon pain, hip pain, and knee pain, systematic reviews and meta-analyses reveal that stem cells from fat and bone marrow with minimal manipulation have not outperformed controls or placebo in clinical studies. Furthermore, research indicates that the quantity of stem cells in typical injectable doses from fat and bone marrow is minuscule and likely incapable of generating significant biological repair. Contrary to claims of safety, clinical studies have reported serious adverse events associated with these procedures. The article contrasts this with the bright future envisioned for rigorously tested, FDA-approved stem cell therapies, such as blood stem cell transplants. Ongoing clinical trials examining the effects of biologically active stem cells with advanced manipulation offer a glimmer of hope for future treatments. The practical takeaway is to be cautious of claims made by commercial clinics, as current data does not support the widespread use of minimally manipulated adult stem cells for musculoskeletal pain.