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Answers from the Lab
Trailer
Bonus
Episode 168
Season 1
CIDP: Divyanshu (Div) Dubey, M.B.B.S.
(00:32)
Would you mind telling our listeners a little about yourself and your background?
Would you mind telling our listeners a little about yourself and your background?
(01:16)
This evaluation is about CIDP — chronic inflammatory demyelinating polyneuropathy, correct?
This evaluation is about CIDP — chronic inflammatory demyelinating polyneuropathy, correct?
(02:16)
Can you give us an overview of what the CIDP evaluation will consist of?
Can you give us an overview of what the CIDP evaluation will consist of?
(04:38)
Our standalone test for neurofascin-155 won't change, but will be rolled into this new test along with contactin-1, correct?
Our standalone test for neurofascin-155 won't change, but will be rolled into this new test along with contactin-1, correct?
(06:41)
This is a very rare disease with subtle clues, so does it make logical sense to pair these two antibodies?
This is a very rare disease with subtle clues, so does it make logical sense to pair these two antibodies?
(08:07)
Why did we choose a cell-binding assay over a western blot or other methodology? Is there a reason why contactin-1 is better on CBA methodology?
Why did we choose a cell-binding assay over a western blot or other methodology? Is there a reason why contactin-1 is better on CBA methodology?
(09:40)
Can you elaborate on what this phenotype-specific approach means for neurologists, and how it makes their ordering easier?
Can you elaborate on what this phenotype-specific approach means for neurologists, and how it makes their ordering easier?
(11:14)
Even though it's hard to determine exactly what test to order for these patients, testing too broadly can just add to the confusion. Is a narrowed evaluation that answers specific questions more helpful?
Even though it's hard to determine exactly what test to order for these patients, testing too broadly can just add to the confusion. Is a narrowed evaluation that answers specific questions more helpful?
(14:42)
Can you give us any clues as to when a physician shouldn't order this test because it's unlikely to be positive?
Can you give us any clues as to when a physician shouldn't order this test because it's unlikely to be positive?
(15:51)
How does this test drive patient care? A lot of these patients are therapy refractory. What would be the second- or third-level treatment? Is there any oncological association with antibody positivity?
How does this test drive patient care? A lot of these patients are therapy refractory. What would be the second- or third-level treatment? Is there any oncological association with antibody positivity?
(18:44)
Are there any alternative options for diagnostic answers for this challenging patient population?
Are there any alternative options for diagnostic answers for this challenging patient population?
(20:44)
What is the key takeaway? What excites you most about this new test launch?
What is the key takeaway? What excites you most about this new test launch?