{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Hard Drugs","title":"Proteins: Weird blobs that do important things","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/00282b05\"></iframe>","width":"100%","height":180,"duration":1189,"description":"This episode kicks off a mini-series on proteins, drug development and AI. Saloni and Jacob explore the world of proteins, including how proteins fold into complex shapes, why that complexity matters and how crowded and dynamic the inside of a cell really is; and they exchange surprising statistics about proteins.\nHard Drugs is a new podcast from Works in Progress and Open Philanthropy about medical innovation presented by Saloni Dattani and Jacob Trefethen.\nYou can watch or listen on YouTube, Spotify, or Apple Podcasts.\nSaloni’s substack newsletter: https://www.scientificdiscovery.dev/\n\nJacob’s blog: https://blog.jacobtrefethen.com/ \n\nBooks:\nRon Milo and Rob Phillips. Biology by the numbers https://book.bionumbers.org/ \nCarl Ivar Branden and John Tooze (1999) Introduction to protein structure https://www.taylorfrancis.com/books/mono/10.1201/9781136969898/introduction-protein-structure-john-tooze-carl-ivar-branden \nArticles:\nNiko McCarty (2023). Biology is a burrito. https://www.asimov.press/p/burrito-biology  \nRhiannon Morris, Katrina Black, and Elliott Stollar (2022) Uncovering protein function: from classification to complexes. https://pmc.ncbi.nlm.nih.gov/articles/PMC9400073/ \nVictor Muñoz and Michele Cerminara (2016) When fast is better: protein folding fundamentals and mechanisms from ultrafast approaches https://portlandpress.com/biochemj/article/473/17/2545/49248/When-fast-is-better-protein-folding-fundamentals \nImage credits:\nChang et al. (2012) Egg white in organic electronics. https://spie.org/news/4149-egg-white-in-organic-electronics [diagram of egg white denaturing and cross-linking]\nJohn Kendrew’s model of myoglobin’s structure; via Carl Ivar Branden and John Tooze (1999) Introduction to protein structure.\nCarl Ivar Branden and John Tooze (1999) Introduction to protein structure. [diagram of amino acids and protein structure]\nRon Milo and Rob Phillips. Which is bigger, mRNA or the protein it codes for?...","thumbnail_url":"https://img.transistorcdn.com/bBbAA3-An3hw3uv_Sf647ZQV-IpESOooEROiyEp4Ytg/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS81MzM2/YTc5NmRlZGI2Zjhi/YWM2ZDk4MzBhZjg4/YTRjMi5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}