{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"632nm","title":"The Science of Drug Discovery: Insights from Artem Evdokimov","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/03fb2d03\"></iframe>","width":"100%","height":180,"duration":10228,"description":"In this episode, drug discovery scientist Artem Evdokimov discusses the science of pharmaceutical development, from historical breakthroughs to the current landscape. He shares insights on antibiotics resistance, the obesity drug Ozempic, and technical details of drug screening methods like DNA-encoded libraries. \nThe conversation covers the economics of drug development, the potential of AI, and broader philosophical questions about human health and medicine. Evdokimov emphasizes the importance of avoiding oversimplification in science while highlighting both the triumphs and ongoing challenges in pharmaceutical research.\n03:18 Historical Roots of Medicine\n05:33 Evolution of Drug Delivery Methods\n12:52 Modern Drug Discovery and Challenges\n45:39 Understanding the Drug Discovery Process\n47:30 Challenges in Gene Therapy\n49:26 Complexities of Human Physiology\n53:14 The Role of Receptors and Hormones\n01:28:12 The Selenium Shortage and Shampoo Dilemma\n01:28:54 Challenges in Drug Manufacturing and Distribution\n01:34:23 Antibiotic Resistance: A Growing Concern\n01:45:18 The Future of Drug Discovery and AI\n02:11:01 Exploring AI and Drug Discovery\n02:11:41 Outsourcing in Pharma: Pros and Cons\n02:13:56 High Throughput Screening and Machine Learning\n02:16:37 Challenges and Future of Drug Discovery\n\nFOLLOW US ON SOCIAL:\nTwitter @ https://x.com/632nmPodcast\nSubstack: https://632nmpodcast.substack.com/\nMichael Dubrovsky @ https://x.com/MikeDubrovsky\nMisha Shalaginov @ https://x.com/MYShalaginov\nXinghui Yin @ https://x.com/XinghuiYin\nSUBSCRIBE:\nApple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269\nSpotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6OR\nWEBSITE:\nhttps://www.632nm.com","thumbnail_url":"https://img.transistorcdn.com/GydlQqnUybBqv7mvA947eCIsz_CyOG8rEnboLv3Hs_I/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8yOGMz/YTliMThlODIyYzYw/OGVjOWNiZWNlNmQ1/ZmQ0Ni5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}