{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2026-02-28","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/091b2eca\"></iframe>","width":"100%","height":180,"duration":149,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们要关注发表在《Trends in pharmacological sciences》(IF:13.9)上的重要论文\"Leveraging conformational ensembles in allosteric drug discovery\"。这项研究彻底改变了我们对蛋白质动态性的理解，揭示了Ras、mTOR和EGFR等信号蛋白如何在生物分子凝聚态中作为动态构象集合体存在。研究挑战了传统药物发现中将蛋白质视为刚性实体的观念，展示了通过高级分子动力学模拟发现的异质动态集合体如何揭示传统方法无法发现的可靶向位点，如隐秘口袋和协同外部位点。这一突破性方法为变构药物设计开辟了新途径，有望开发出更有效的癌症治疗策略。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}