{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-09-29","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/1716c96b\"></iframe>","width":"100%","height":180,"duration":186,"description":"科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Circulation(影响因子35.5)上的重要研究\"Single-Cell Splicing Isoform Atlas of the Adult Human Heart and Heart Failure\"。该研究首次绘制了成人心脏单细胞剪接异构体图谱，发现异构体异质性在心脏细胞系统中广泛存在，作为转录后缓冲系统调节心脏功能。研究揭示，与健康心脏相比，心力衰竭患者心肌细胞中379个基因出现明显异构体使用变化，这些变化可能改变蛋白质功能。这项突破性发现为理解心脏疾病机制和开发新疗法提供了重要参考，数据资源已公开供全球科学家访问研究。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}