{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-09-23","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/1b224a17\"></iframe>","width":"100%","height":180,"duration":110,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。\n\n本期内容关注一项发表在《European Heart Journal》(IF: 37.6)上的重要研究：\"Shear stress-induced endothelial HEG1 signalling regulates vascular tone and blood pressure.\" 该研究揭示了血管内皮细胞中的HEG1蛋白如何通过感知血流剪切应力来调节血管张力和血压。研究发现高血压患者血浆HEG1水平降低，这与其内皮剪切应力减少有关。在实验中，特异性删除内皮细胞中的Heg1基因会导致小鼠血压升高和血管舒张功能受损。机制上，HEG1通过促进CUL3介导的PHACTR1降解，维持内皮型一氧化氮合酶(eNOS)的正常表达和一氧化氮产生。这一发现为高血压治疗提供了新的潜在靶点，通过调节这一剪切敏感的内皮HEG1信号通路，可能成为未来干预高血压的重要策略。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}