{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"The New Biology","title":"Magnet-Controlled Medicines — Andrew York & Maria Ingaramo","html":"","width":"100%","height":180,"duration":7656,"description":"Nonfiction Laboratories is building a technology called “magnetogenetics” that promises to control proteins inside the body — such as antibodies or enzymes — using small magnets. In this episode, co-founder Maria Ingaramo and scientific advisor Andrew York explain how they engineered a protein, MagLOV, that responds strongly to magnetic fields, why most prior attempts have failed to replicate, and how the mechanism of magnetically-controlled proteins actually works. They also get into the “dream” use cases, like cancer drugs that activate only at the tumor, which might have a lower toxicity inside the body. \nThis podcast is made possible by Astera Institute.\nNotes from our discussion: https://nikomc.com/essays/protein-magnets.html\n00:00 - Opening\n00:54 — Introduction\n01:35 — The dream\n05:38 — Why magnets vs. light or ultrasound\n10:05 — The physics\n17:48 — On the name \"magnetogenetics\"\n21:25 — Birds and cryptochromes\n27:09 — Why is the field filled with so much junk?\n29:51 — Adam Cohen's molecule\n33:24 — Markus Meister’s debunking\n38:06 — The experiment\n46:22 — Finding the LOV domain\n54:11 — Singlets, triplets, and cysteine\n56:54 — What the magnet is actually doing\n1:05:13 — The conformational-change red herring\n1:12:46 — The Quantum Biology Institute\n1:19:31 — Founding Nonfiction Labs\n1:24:38 — How to convince skeptical investors\n1:29:39 — What a magnetogenetic medicine might look like\n1:38:50 — First clinical indications\n1:45:12 — The regulatory path\n1:48:01 — What the field needs\n1:54:30 — Appendix: Whiteboard lecture","thumbnail_url":"https://img.transistorcdn.com/Cdlp_4Y2x0oxnTGtoVdklrgCMQQ-ARclU1VI-dDVZCI/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9jYTRi/NTg1Yzc3YmRiZjg1/ZjNmYmNkNjAyYjFl/NjllMS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}