{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-10-01","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/1f6c9918\"></iframe>","width":"100%","height":180,"duration":260,"description":"科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注一项发表在影响因子16.4的《Accounts of Chemical Research》上的重要研究，题为\"Molecular Insights into Bismuth's New Applications against Antimicrobial Resistance and Coronaviruses\"。这项突破性研究揭示了铋这种低毒性重金属的新治疗潜力。研究发现铋不仅能对抗抗生素耐药性，还能作为金属β-内酰胺酶的广谱抑制剂，与现有抗生素协同对抗耐药菌。更令人兴奋的是，铋能破坏冠状病毒的关键锌指蛋白，与N-乙酰半胱氨酸结合可提高对SARS-CoV-2的疗效。这些发现为应对全球抗生素耐药危机和冠状病毒感染提供了全新的治疗策略，展现了老药新用的巨大潜力。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}