{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-09-14","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/1f7eaea5\"></iframe>","width":"100%","height":180,"duration":157,"description":"【科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载】\n\n本期关注发表在《Trends in biotechnology》(IF: 14.3)上的重要研究\"Semi-automated biofoundry workflows for sequence coevolution-guided isoprene synthase engineering\"。研究团队开发了一种半自动化生物铸造厂工作流程，通过整合序列共进化分析和实验室自动化，成功改造了异戊二烯合酶(IspS)。经过三轮定向进化，他们获得了催化效率提升4.5倍且热稳定性增强的IspS变体，并将其应用于甲烷到异戊二烯的生物转化，产量达到319.6 mg/l。这一突破性方法为生物制造领域提供了可扩展的酶工程框架，有望推动生物燃料和特种化学品生产的革新性进展。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}