{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"The Nichole Wischoff Podcast","title":"Inside NewLimit: A $1.6B Biotech Startup Solving Aging","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/27090555\"></iframe>","width":"100%","height":180,"duration":2283,"description":"In today’s episode, we sit down with Jacob, co-founder & CEO of NewLimit, a company that has raised $247M to push the frontier of aging science  from epigenetic reprogramming to AI-driven drug discovery.\nWe dive deep into how NewLimit plans to restore youthful function in human cells, what’s actually possible with aging reversal, how AI accelerates drug discovery, why GLP-1s changed the game, and whether there’s a real chance that none of this works.\nIf you're curious about biology, longevity, AI in drug discovery, or what it takes to build a $1.5B+ biotech startup from scratch this episode is a must-watch.\nTimestamps\n00:00 – 00:58\n How epigenetic reprogramming works & why aging might be reversible\n00:58 – 01:03\n How big AI models changed biotech\n01:03 – 02:21\n NewLimit’s origin story — Jacob, Brian Armstrong & Blake Byers\n02:22 – 05:20\n Early breakthroughs, skeptical experiments & why results surprised them\n05:20 – 08:25\n Choosing the first targets: liver, immunity & where aging hits hardest\n08:25 – 11:35\n AI in drug discovery — protein language models, predicting experiments, and cutting years of R&D\n11:35 – 14:10\n What medicines could actually make us “feel” younger?\n14:10 – 16:15\n Diseases of aging vs. problems that hit everyone after 25\n16:15 – 19:10\n How biotech actually works — discovery → development → commercialization\n19:10 – 21:00\n Why Eli Lilly invested & how a drug goes to market\n21:00 – 23:30\n How close NewLimit is to human trials\n23:30 – 25:50\n What needs to happen before a drug ever touches a human\n25:50 – 27:45\n Phase 1, 2, 3 trials explained simply\n27:45 – 29:20\n Building the team: from 5 scientists to a world-class 40-person biotech\n29:20 – 31:20\n Why staying small is a superpower in biotech\n31:20 – 33:10\n Fundraising: why aging reversal needs $200M+ instead of $5M\n33:10 – 35:10\n Is there a chance they discover nothing? Startup-like risk in drug discovery\n35:10 – 38:02\n What Jacob is most excited about: GLP-1s, diagnostics, AI & the future of...","thumbnail_url":"https://img.transistorcdn.com/z6FKzAz7OPycDWz7mqcSseCBVR1WM20qrJciEzt8RyE/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS80MDAz/OGFlYzc1ZjFmMTZh/OGMxZDcwMTgzZjVj/Y2ExOS5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}