{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Thyroid Mystery Solved: Hashimoto's and Hypothyroidism Revealed","title":"084 When is CBD the Only Option for Pain?","html":"","width":"100%","height":180,"duration":2166,"description":"The Case:  Paulina is dealing with tension and constant pain in her upper back and neck.  She’s also experiencing frequent sleep interruptions, headaches and her body is in a constant state of inflammation. Paulina tried adjusting her work set up, saw doctors and a chiropractor, following their advice to take NSAIDs and anti-inflammatory medications but they left her with a sore stomach and still in pain. Natural anti-inflammatories (like fish oil and curcumin) only dulled the pain without decreasing inflammation. When it comes to inflammation and pain, many things are at play and like most things in health, things are interconnected. We often talk about inflammatory cytokines but my instinct was that there really was more going on and we had to dig to find the root cause.   The Investigation My instinct was to focus on the endocannabinoid system, which I suspected might assist in understanding and solving Paulina’s case.  When I went over the history and looked at all the things that she tried for inflammation, my sense was that she may not be able to process the inflammation properly because another system was dysregulated. Pat Gawrysiak is a formulation scientist and the Founder and CEO of RSPrecision Pharma, a pharmaceutical manufacturing and compounding company and President of 7 Leaf Compounds, (a company that grows and manufactures CBD products). I knew he’d be the ideal person to speak with about this. Endocannabinoid System and Clinical Endocannabinoid Deficiency Endocannabinoids are a system of cell receptors. This molecular system balances many body processes, such as immune response, cell communication, appetite, mood, metabolism, memory, and sleep. Phytocannabinoids are plant molecules, such as Tetrahydrocannabinol (THC), CBD-A, CBD-G, and CBD-N. The phytocannabinoids are from plants, and endocannabinoids are from mammals.  High quality CBD products are known to activate the CB-1 and CB-2 receptors.  Clinical endocannabinoid deficiency is a medical...","thumbnail_url":"https://img.transistorcdn.com/9ZbRr0xzgu8-YRnig2AcyeY_Nu_m2EBquTr83LV8K2g/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9zaG93/LzQ4NTg5LzE3MTE1/NjQxMDktYXJ0d29y/ay5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}