{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2026-03-15","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/2ad84e12\"></iframe>","width":"100%","height":180,"duration":197,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们关注发表在《Nucleic acids research》(影响因子16.6)上的重要研究：\"EEP evolved a unique DNA clamping dimer protecting reversed replication forks.\"这项突破性研究揭示了EEPD1蛋白的独特工作机制——它通过形成前所未有的色氨酸\"握手\"二聚体，夹住反转复制叉的双链DNA，从而保护基因组稳定性。研究发现EEPD1并非传统认知中的核酸酶，而是通过防止MRE11对复制叉的降解来维持DNA完整性。癌症生物信息学分析表明，EEPD1与氧化损伤相关联，显著影响患者生存率。这一发现不仅深化了我们对氧化应激反应的理解，还为癌症治疗提供了潜在的新靶点。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}