{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-10-17","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/2df4aefa\"></iframe>","width":"100%","height":180,"duration":207,"description":"科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Nucleic acids research》(IF:16.6)上的重要研究：\"Dysregulation of AGO2-miRNA dynamics underlies the AGO2-associated Lessel-Kreienkamp syndrome.\"这项研究揭示了AGO2基因突变如何导致神经发育障碍。科学家发现多种AGO2突变通过改变miRNA靶向动力学，以功能获得方式影响神经元转录组。特别是L192P突变不仅延长了靶RNA停留时间，还改变了miRNA加载和选择性，导致小鼠模型中繁殖能力下降和皮层转录组异常。这一发现为理解Lessel-Kreienkamp综合征的分子机制提供了新视角，并为开发针对性治疗策略奠定了基础。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}