{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"632nm","title":"Biology's Biggest Chicken and Egg Problem | Jacob Fine","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/307c1f9c\"></iframe>","width":"100%","height":180,"duration":5464,"description":"Life’s First Blueprint Wasn’t DNA; it was RNA.\nRead Jacob Fine’s latest publication here: https://www.sciencedirect.com/science/article/pii/S0022283625001901\nToday we spoke with Jacob Fine, graduate student researcher in Computational Biology from the University of Toronto. We explore the physics of replication, the role of entropy and information theory, and how modern biology is reconnecting with theory to understand the most fundamental question in science. Our conversation takes place in a Russian sauna, where the hot and humid environment mimics some of the conditions needed for life to begin.\n\nFollow us for more technical interviews with the world’s greatest scientists:\nTwitter: https://x.com/632nmPodcast\nInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==\nLinkedIn: https://www.linkedin.com/company/632nm/about/\nSubstack: https://632nmpodcast.substack.com/\nFollow our hosts!\nMichael Dubrovsky: https://x.com/MikeDubrovsky\nMisha Shalaginov: https://x.com/MYShalaginov\nXinghui Yin: https://x.com/XinghuiYin\nSubscribe:\nApple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269\nSpotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6OR\nWebsite: https://www.632nm.com\nTimestamps:\n00:00 - Intro\n01:22 - What does any theory of the origin of life need to explain?\n04:09 - When did people begin researching the origin of life?\n06:51 - Competing theories of the origin of life\n11:00 - The RNA world hypothesis\n21:38 - Biological vs computational error\n24:58 - Origin of life is the origin of information\n33:30 - Without error, there would be no life\n36:07 - Early compartmentalization mechanisms\n47:26 - What do we need to prove theories on the origin of life?\n57:23 - What makes a useful model for biology?\n1:04:44 - What inspired Jacob to investigate the origin of life?\n1:09:45 - Jacob's favorite theories for the origin of life\n1:11:58 - Do we need a Manhattan project to discover the origin of life?\n1:18:49...","thumbnail_url":"https://img.transistorcdn.com/GydlQqnUybBqv7mvA947eCIsz_CyOG8rEnboLv3Hs_I/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8yOGMz/YTliMThlODIyYzYw/OGVjOWNiZWNlNmQ1/ZmQ0Ni5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}