{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-09-14","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/31d5ac96\"></iframe>","width":"100%","height":180,"duration":172,"description":"科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Trends in biotechnology(影响因子14.3)上的重要研究\"Semi-automated biofoundry workflows for sequence coevolution-guided isoprene synthase engineering\"。这项研究开发了一套适用于生物铸造厂的规模化酶工程工作流程，通过整合序列共进分析和自动化技术，成功将异戊二烯合酶的催化效率提高了4.5倍，同时增强了热稳定性。研究团队将工程化酶应用于甲烷转化异戊二烯的生物过程，产量达到319.6 mg/l。这一突破性方法为生物制造领域的酶工程提供了强大框架，有望加速生物技术的创新发展。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}