{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Hard Drugs","title":"The art of protein design with AI","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/31e0639d\"></iframe>","width":"100%","height":180,"duration":3621,"description":"What if you could design a protein never seen in nature? In this episode, Jacob and Saloni explore how researchers are using new tools like RFDiffusion, AlphaFold, and ProteinMPNN to ‘hallucinate’ entirely novel proteins: designing them from scratch to solve problems evolution hasn’t tackled. They talk about how these technologies could transform medicine, agriculture, and materials science. Along the way, they reflect on the surprising ways AI is changing the process of science itself.\nHard Drugs is a new podcast from Works in Progress and Open Philanthropy about medical innovation presented by Saloni Dattani and Jacob Trefethen.\nSaloni’s substack newsletter: https://www.scientificdiscovery.dev/\n\nJacob’s blog: https://blog.jacobtrefethen.com/ \n\nCourses:\nEMBL-EBI. AlphaFold: A practical guide https://www.ebi.ac.uk/training/online/courses/alphafold/ \nArticles:\nTanja Kortemme (2024) De novo protein design—From new structures to programmable functions https://www.cell.com/cell/fulltext/S0092-8674(23)01402-2 \nJie Zhu et al. (2021) Protein Assembly by Design https://pubs.acs.org/doi/10.1021/acs.chemrev.1c00308 \nLectures:\nRosetta Commons (2024) Diffusion models for protein structure generation (and design) https://www.youtube.com/watch?v=OEnY2yA3jy8 \nRosetta Commons (2024) AlphaFold – ML for protein structure prediction https://www.youtube.com/watch?v=SVrn8_8aKO8 \nRosetta Commons (2024) MPNN – ML for protein sequence design https://www.youtube.com/watch?v=6z4XmUAwdNA \nAcknowledgements:\nAria Babu, editor at Works in Progress\nGraham Bessellieu, video editor\nRachel Shu, on-site editor\nAnna Magpie, fact-checking\nAbhishaike Mahajan, cover art\nAtalanta Arden-Miller, art direction\nDavid Hackett, composer\nWorks in Progress & Open Philanthropy","thumbnail_url":"https://img.transistorcdn.com/bBbAA3-An3hw3uv_Sf647ZQV-IpESOooEROiyEp4Ytg/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS81MzM2/YTc5NmRlZGI2Zjhi/YWM2ZDk4MzBhZjg4/YTRjMi5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}