{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-肿瘤学","title":"今日肿瘤学最高分文献 - 2025-10-17","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/36d0187c\"></iframe>","width":"100%","height":180,"duration":146,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《International journal of molecular medicine》(影响因子5.7)上的重要综述\"Cholesterol metabolism and cancer: Molecular mechanisms, immune regulation and an epidemiological perspective\"。这项研究揭示了胆固醇代谢与癌症之间的复杂联系，发现癌细胞通过重塑胆固醇稳态促进肿瘤侵袭和转移。胆固醇在肿瘤免疫微环境中展现双重角色：既增强T细胞抗肿瘤功能，其氧化衍生物又导致T细胞耗竭。研究指出，靶向胆固醇代谢可能是触发铁死亡、逆转耐药性和重新激活抗肿瘤免疫的新策略，为癌症治疗提供了全新视角。","thumbnail_url":"https://img.transistorcdn.com/3WX36CzvFOrNjlF7WfWjzS4HdcMIMmzMs2bmPS-ejLU/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS83NDNm/MjQ1N2E5NjhjMzVj/NjM0ZTA3YzY2NDE2/ZmIyMi5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}