{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2026-02-08","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/390dc569\"></iframe>","width":"100%","height":180,"duration":216,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。\n\n本期关注发表在《Journal of Hepatology》(IF: 26.8)上的重要研究\"Macrophage-derived cathepsin B disrupts intestinal tight junctions through occludin degradation and promotes alcohol-associated liver disease\"。这项突破性研究发现，肠道巨噬细胞产生的蛋白酶组织蛋白酶B通过降解紧密连接蛋白occludin破坏肠道屏障，促进酒精相关肝病进展。研究证实，抑制组织蛋白酶B可稳定肠道屏障，降低血清内毒素水平，减轻酒精性肝炎症状。这一发现为目前治疗手段有限的酒精相关肝炎提供了新的治疗靶点，有望改变临床实践。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}