{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-11-11","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/3f7d03f2\"></iframe>","width":"100%","height":180,"duration":226,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。\n\n本期关注发表在《Cancer letters》(IF:9.1)上的重要研究\"KLF7 as a biomarker in the pre-metastatic state promotes colorectal liver metastasis via TGFβ autocrine signaling\"。该研究首次确定了转移前状态(PMS)细胞的两个亚型，并发现KLF7是PMS1的关键生物标志物，通过激活TGFβ自分泌信号促进结直肠癌肝转移。更令人振奋的是，研究证实表没食子儿茶素没食子酸酯(EGCG)可抑制KLF7活性，为高表达KLF7的结直肠癌提供了新的治疗策略。这项突破性发现不仅深化了对转移机制的理解，更为临床干预提供了潜在靶点。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}