{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Epilepsy Sparks Insights","title":"Why Don't Antiseizure Medications Work for Everyone? - Graeme Sills, PhD","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/40f2cc68\"></iframe>","width":"100%","height":180,"duration":1110,"description":"Why do around 30% of people with epilepsy still have uncontrolled seizures despite decades of new antiseizure medications? Graeme Sills, PhD, explains the leading theories behind drug resistance - and how a better understanding of the brain could transform future epilepsy treatments.\nChapters 📖\n00:00 Trailer & intro\n00:45 Meet Graeme Sills\n01:29 Introduction to pharmacology and epilepsy\n02:17 Challenges in epilepsy reatment\n06:30 Why the drugs don’t work: the drug-transporter hypothesis\n08:38 Why the drugs don’t work: the network hypothesis\n09:31 Why the drugs don’t work: the severity and genetic hypothesis\n10:06 Future directions in epilepsy research\n13:08 Innovative approaches to research and treatment?\n17:58 Closing thoughts & thanks\n🔗 Episode page and transcript epilepsysparks.com/epilepsy-sparks-insights/pharmacology-past-present-future\n🌐 More about Graeme epilepsysparks.com/guests/graeme-sills\n🌐 More Epilepsy Sparks Insights epilepsysparks.com/epilepsy-sparks-insights\n🎥 Watch on YouTube youtube.com/@EpilepsySparksInsights\n🔤 Don’t understand terms used? Check out the Epilepsy Sparks Glossary epilepsysparks.com/glossary\n📲 Join us on social media!\n〰️ LinkedIn epilepsy-sparks\n〰️ Instagram epilepsysparks\n〰️ Facebook epilepsysparks\n〰️ TikTok epilepsysparks\n〰️ Bluesky epilepsysparks​","thumbnail_url":"https://img.transistorcdn.com/ETcVcvJ4VhVWwS3naEn8WMtHF9g3yTGGq7gx0U5XJZo/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9jMzZm/NGY5NWZmMTgxMGZi/MjE0ODNkMjI2NGRk/YjJjNC5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}