{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Paradigm Pulse","title":"New and Emerging Mechanisms in the Treatment of Systemic Lupus Erythematosus","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/45ae9d98\"></iframe>","width":"100%","height":180,"duration":2343,"description":"Please CLICK HERE (https://activities.paradigmmc.com/1460P) to view the full CME activity and claim credit for your participation.\nB cells play a major role in the pathology of systemic lupus erythematosus (SLE), and several treatments have focused on blocking activation or depleting large subsets of B cells based on surface markers. From anti-CD20 antibodies to chimeric antigen receptor (CAR) T cells, varying depths of B-cell depletion have demonstrated a range of efficacies and durations of response. In addition, these treatments vary in administration, preparation, ease of use, and potential adverse effects. The faculty will provide an engaging discussion on the categories of emerging B-cell therapies and their potential use in SLE.","thumbnail_url":"https://img.transistorcdn.com/Uga14-1SmzHVb_rXfrAl7wxgvvV-lL_x9hXWDhPo6b0/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9mYmRi/ZmZmYTBlN2UwZDVj/MzFjZmZjZTdlMWFm/YmMzNi5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}