{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Blood Cancer Talks","title":"Episode 67. Management of CMV in Hematologic Malignancies","html":"","width":"100%","height":180,"duration":2401,"description":"Join hosts Eddie, Ashwin, and Raj as they welcome Dr. Michelle Yong and Dr. Gemma Reynolds, academic infectious diseases physicians from the Peter MacCallum Cancer Centre and the National Centre for Infections in Cancer, for an in-depth discussion on cytomegalovirus (CMV) management in immunocompromised hematology patients.\nKey Topics Covered\nFundamentals of CMV Management\nDistinguishing CMV reactivation from CMV disease\nTreatment thresholds and target viral loads\nProphylaxis strategies in non-allograft settings\nValaciclovir dosing in general hematology populations\nHigh-risk patient populations\nFirst-Line Therapies\nValganciclovir: advantages, disadvantages, and myelosuppression\nFoscarnet: indications and monitoring strategies\nTreatment-resistant CMV\nAllogeneic Transplant Patients\nHigh-risk populations and timing of reactivation\nMonitoring protocols post-transplant\nRandomized Controlled Trials\nAURORA Trial: Maribavir vs. Valganciclovir\nDesign: RCT comparing maribavir to valganciclovir for pre-emptive CMV therapy post-allogeneic transplant [https://pubmed.ncbi.nlm.nih.gov/38036487/]\nNEJM Letermovir Prophylaxis Trial\nDesign: Double-blind, placebo-controlled RCT of letermovir prophylaxis post-allogeneic transplant [https://pubmed.ncbi.nlm.nih.gov/29211658/]\nEmerging Patient Populations\nCMV in lymphoma and myeloma patients receiving CAR T-cell therapy and T-cell engaging bispecific antibodies\nMonitoring and prophylaxis strategies for novel immunotherapies\nImpact of CMV on post-CAR T mortality-https://pubmed.ncbi.nlm.nih.gov/40203190/","thumbnail_url":"https://img.transistorcdn.com/sqlYzk0Oxhchi1Lmft_9Md8dG97D7hyy2rwRG7COuc0/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9zaG93/LzMyMDc4LzE2NTcz/MTQxMDUtYXJ0d29y/ay5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}