{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-10-23","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/4a7003fd\"></iframe>","width":"100%","height":180,"duration":223,"description":"科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。\n\n本期关注发表在《Cancer Research》(IF: 12.5)上的重要研究：\"RORγ Hijacks HIF-1α to Promote Peritoneal Metastasis of Gastric Cancer\"。该研究揭示了胃癌腹膜转移的关键机制——RORγ通过劫持HIF-1α，形成正反馈循环，促进胃癌细胞适应缺氧微环境并加速转移。研究团队发现，RORγ能保护HIF-1α不被降解，激活缺氧反应和上皮-间质转化相关基因，从而驱动肿瘤进展。更令人振奋的是，使用RORγ拮抗剂可有效阻断这一过程，不仅抑制肿瘤生长和转移，还能增强化疗敏感性，为晚期胃癌腹膜转移提供了新的治疗策略。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}