{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"NephSpace","title":"Weekly · Oct 2: The Middle-Molecule Race, a Dipstick Adherence Check, and AI for Fellows","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/4b28f8c3\"></iframe>","width":"100%","height":180,"duration":1856,"description":"Two ways to clear more middle molecules arrive in US dialysis units at once. A urine dipstick can show whether patients are taking their SGLT2 inhibitor. Two papers disagree about who should let AI write the notes. Nine picks from the week of September 21, 2026, each with the story, the numbers and a take.\n\nDisclosure: Dr. Hussein serves on the Fresenius Medical Care US Home Medical Advisory Board. Fresenius sells hemodiafiltration machines, which are discussed in this episode.\n\nChapters\n00:00 Cold open and running order\n01:10 Hemodiafiltration: a JASN review makes the case for high-volume HDF as the global default, and how to prescribe it\n05:06 Medium cutoff dialyzers: Nipro's ELISIO-HX is cleared in the US and DaVita is scaling it up. What the interview shows, and what it doesn't\n08:13 Obinutuzumab: FDA approval for preventing relapse in frequently relapsing or steroid-dependent childhood-onset nephrotic syndrome, from age 2 into adulthood\n11:08 Nephrology and CKM syndrome: an AJKD perspective on shifting the specialty from organ failure to prevention\n13:59 Atherosclerosis in CKD: a CJASN review of mechanisms, risk prediction and the treatment menu\n17:54 GLP-1 receptor agonists in CKD: a case-based CJASN \"How I Treat\" piece\n21:03 The dipstick adherence check: glucosuria on routine urinalysis as a marker that patients are taking their SGLT2 inhibitor\n24:31 AI in practice: where AI can take paperwork off the nephrologist's desk\n27:44 Fellows and AI: training for the AI era without \"never-skilling\"\n30:24 Close\n\nPapers and news in this episode\nBlankestijn PJ, et al. Hemodiafiltration: Clinical Practice of Today and a Look into the Future. JASN 2026 (ahead of print). https://doi.org/10.1681/ASN.0000001282\nHealio | Nephrology, September 24, 2026. Q&A with DaVita's chief medical officer: recent FDA approval prompts expansion of medium cutoff dialyzers. https://www.healio.com/news/nephrology/20260924/qa-recent-fda-approval-prompts-expansion-of-medium-cutoff-dialyzers...","thumbnail_url":"https://img.transistorcdn.com/qEB_C2DMBeK5C7ck76pmhOTj2_OsMU1iYzmZ4jzilE8/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9kZDYw/YjRhODU0MTA5MDRj/Y2YwNTQ3OThmNzE5/YmI4ZC5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}