{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-10-20","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/548a7a86\"></iframe>","width":"100%","height":180,"duration":257,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表于《Circulation》(影响因子35.5)的重要研究\"ALDH2/eIF3E Interaction Modulates Protein Translation Critical for Cardiomyocyte Ferroptosis in Acute Myocardial Ischemia Injury\"。这项研究发现，影响约40%东亚人群的ALDH2*2基因变异通过促进含特定基序mRNA的选择性翻译，驱动心肌细胞铁死亡，加重心肌梗死后急性心力衰竭。研究团队通过临床队列和动物模型证实，铁死亡抑制剂可显著改善心脏功能。这一发现不仅揭示了心肌损伤的新机制，还为心肌梗死治疗特别是ALDH2*2携带者提供了潜在新靶点。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}