{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-11-26","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/58b199a8\"></iframe>","width":"100%","height":180,"duration":186,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Nature（IF:50.5）上的重要研究\"Polyclonal origins of human premalignant colorectal lesions\"。这项研究挑战了传统癌症理论，发现结直肠癌前病变可能起源于多个不同遗传背景的细胞克隆，而非单一突变细胞。通过分析家族性腺瘤性息肉病患者的123个样本，研究人员发现40%的良性息肉和28%的发育不良息肉均由多个遗传谱系组成，且部分息肉中存在不同的APC突变。这一发现颠覆了我们对肿瘤起始机制的认识，强调了微环境和组织因素在早期癌症进化中的关键作用，为癌症预防和干预提供了新思路。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}