{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-代谢","title":"今日代谢学最高分文献 - 2025-10-25","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/592e984f\"></iframe>","width":"100%","height":180,"duration":168,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Gut(影响因子23.0)上的重要研究\"SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL\"。这项突破性发现揭示了SIRT6在肝内胆管癌中的致癌作用，通过增强GLUL促进谷氨酰胺代谢重编程。研究团队证实SIRT6在ICC中高表达，其沉默可显著抑制肿瘤生长并增强化疗敏感性。这一发现不仅阐明了SIRT6-GLUL轴在ICC发展中的关键机制，更为靶向治疗提供了新思路，为改善肝内胆管癌患者预后带来希望。","thumbnail_url":"https://img.transistorcdn.com/xy7e4UKltIRfCpZXt83xlcjDVENiWPx7z0QccPHtrxA/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS83ZTA5/ODVlZWM0NzFjMzM1/NmIzODRlYTMzODU4/MTU5ZS5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}