{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-代谢","title":"今日代谢学最高分文献 - 2025-10-31","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/5dfede12\"></iframe>","width":"100%","height":180,"duration":261,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Circulation Research (IF: 16.5)上的重要研究\"YAP-Induced Glycolysis Drives Fibroinflammation and Disrupts Fibroblast Fidelity\"。这项突破性研究发现，右心房成纤维细胞比其他心室更具糖酵解活性且YAP活性更高。研究揭示YAP激活会诱导糖酵解，进而驱动纤维化，同时破坏成纤维细胞谱系保真性，使其向骨软骨祖细胞状态转变。更令人惊讶的是，YAP通过激活CSF1分泌促进巨噬细胞扩张，而巨噬细胞又分泌IGF1进一步增强成纤维细胞增殖和纤维化。通过抑制糖酵解或阻断巨噬细胞扩张，研究人员成功减轻了纤维化进程，为心脏纤维化治疗提供了全新靶点，有望改变心力衰竭等疾病的治疗格局。","thumbnail_url":"https://img.transistorcdn.com/xy7e4UKltIRfCpZXt83xlcjDVENiWPx7z0QccPHtrxA/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS83ZTA5/ODVlZWM0NzFjMzM1/NmIzODRlYTMzODU4/MTU5ZS5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}