{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"632nm","title":"How Bacteria Evolved Rotary Motors | Michael Manson","html":"","width":"100%","height":180,"duration":12370,"description":"How do bacteria power one of the most sophisticated molecular machines in nature?\nIn this episode, we speak with Dr. Michael Manson, one of the pioneers of bacterial motility research, whose nearly 50-year career has helped uncover how the bacterial flagellar motor works. From the first experiments proving that bacterial flagella rotate to the latest breakthroughs in cryo-EM and single-molecule biology, Manson tells the story of how scientists finally solved the mechanism behind a real working biological motor.\nWe explore how bacteria move through chemotaxis using a biased random walk, why E. coli alternates between running and tumbling, and how individual molecules can control the direction of a spinning flagellum. Manson explains the experiments that showed proton motive force powers the flagellar motor, how the motor’s rotor and stator generate torque, why it can reverse direction almost instantly, and how bacteria adapt to changing environments by dynamically adjusting their molecular machinery.\nWe also discuss ATP synthase, proton gradients, molecular motors, bacterial genetics, cryo-electron microscopy, ion channels, self-assembling protein complexes, nanomachines, and the history of the discoveries that transformed modern microbiology.\nWhether you’re interested in the bacterial flagellar motor, molecular biology, biophysics, microbiology, ATP synthase, chemotaxis, molecular machines, or the fundamental physics of life, this week we go deep into one of biology’s most remarkable inventions.\nFollow us for more technical interviews with the world’s greatest scientists:\nTwitter: https://x.com/632nmPodcast\nInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==\nLinkedIn: https://www.linkedin.com/company/632nm/about/\nSubstack: https://632nmpodcast.substack.com/\nFollow our hosts!\nMikhail Shalaginov: https://www.linkedin.com/in/mikhail-shalaginov/\nMichael Dubrovsky: https://www.linkedin.com/in/michael-dubrovsky/...","thumbnail_url":"https://img.transistorcdn.com/GydlQqnUybBqv7mvA947eCIsz_CyOG8rEnboLv3Hs_I/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8yOGMz/YTliMThlODIyYzYw/OGVjOWNiZWNlNmQ1/ZmQ0Ni5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}