{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Answers from the Lab","title":"Assay identifies biomarker of autoimmune encephalitis subtype: Andrew McKeon, M.B., B.Ch., M.D.","html":"","width":"100%","height":180,"duration":1062,"description":"Antibody against the GABA-A receptor is a biomarker of autoimmune encephalopathy that occurs across the lifespan, and disproportionately affects children. In this test-specific episode of the \"Answers From the Lab\" podcast, Andrew McKeon, M.B., B.Ch., M.D., explains how Mayo Clinic Laboratories' GABA-A receptor antibody assay aids diagnosis of this serious but treatable condition.\nShow notes\n(00:32)\nCould you provide a little information on your role here at Mayo Clinic?\n \n(01:11)\n Can you give an introduction as to how GABA-A is important as the field of autoimmune neurology develops?\n \n(02:15)\n What type of methodology are we using in this assay?\n \n(03:17)\n Will there be a reflex to confirm positivity, or is that captured in that initial test?\n \n(04:22)\n Is either CSF or serum specimen preferable, or do we recommend both for this biomarker?\n \n(05:09)\n In combination with what phenotypes should this biomarker be considered?\n \n(05:37)\n Should a physician consider adding a GABA-A receptor standalone test to our encephalopathy, epilepsy, or pediatric evaluations, to be sure they're doing a comprehensive review?\n \n(06:25)\n Can you give us a little background on why this test is being launched by itself? Is Mayo Clinic Labs changing its stance on whether comprehensive evaluations are the most appropriate method?\n \n(07:30)\n Why has it taken so long to bring this assay live?\n \n(08:14)\n For exactly what type of patients should physicians consider this testing?\n \n(10:21)\n Should physicians add our encephalopathy evaluation every time they order GABA-A? Is the presentation you just described common or a subset?\n \n(11:24)\n Does that recommendation change in pediatric patients?\n \n(12:20)\n What does a positive result tell physicians?\n \n(12:57)\n Does GABA-A have a high-risk oncological association?\n \n(13:18)\n What does GABA-A tell a pediatric neurologist if the test comes back positive?\n \n(14:14)\n Should a positive GABA-A test lead a physician to a certain treatment option?\n ...","thumbnail_url":"https://img.transistorcdn.com/jhRCftFebxnTMwoIbA_WoqrSKwFRD_Y2kbh0JDjhx14/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9lYjNj/ZDc0NTE0MWNlOWRl/YzRiN2Q3NDg2Mjg5/YWE4MS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}