{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Answers from the Lab","title":"Assay identifies biomarker of autoimmune encephalitis subtype: Andrew McKeon, M.B., B.Ch., M.D.","html":"","width":"100%","height":180,"duration":1062,"description":"Antibody against the GABA-A receptor is a biomarker of autoimmune encephalopathy that occurs across the lifespan, and disproportionately affects children. In this test-specific episode of the \"Answers From the Lab\" podcast, Andrew McKeon, M.B., B.Ch., M.D., explains how Mayo Clinic Laboratories' GABA-A receptor antibody assay aids diagnosis of this serious but treatable condition.Show notes(00:32) Could you provide a little information on your role here at Mayo Clinic? (01:11) Can you give an introduction as to how GABA-A is important as the field of autoimmune neurology develops? (02:15) What type of methodology are we using in this assay? (03:17) Will there be a reflex to confirm positivity, or is that captured in that initial test? (04:22) Is either CSF or serum specimen preferable, or do we recommend both for this biomarker? (05:09) In combination with what phenotypes should this biomarker be considered? (05:37) Should a physician consider adding a GABA-A receptor standalone test to our encephalopathy, epilepsy, or pediatric evaluations, to be sure they're doing a comprehensive review? (06:25) Can you give us a little background on why this test is being launched by itself? Is Mayo Clinic Labs changing its stance on whether comprehensive evaluations are the most appropriate method? (07:30) Why has it taken so long to bring this assay live? (08:14) For exactly what type of patients should physicians consider this testing? (10:21) Should physicians add our encephalopathy evaluation every time they order GABA-A? Is the presentation you just described common or a subset? (11:24) Does that recommendation change in pediatric patients? (12:20) What does a positive result tell physicians? (12:57) Does GABA-A have a high-risk oncological association? (13:18) What does GABA-A tell a pediatric neurologist if the test comes back positive? (14:14) Should a positive GABA-A test lead a physician to a certain treatment option? (15:24) What are you most excited about in...","thumbnail_url":"https://img.transistorcdn.com/jhRCftFebxnTMwoIbA_WoqrSKwFRD_Y2kbh0JDjhx14/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9lYjNj/ZDc0NTE0MWNlOWRl/YzRiN2Q3NDg2Mjg5/YWE4MS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}