{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"The Dr Kumar Discovery","title":"The Cancer Add-On Therapies Most Oncologists Never Mention | Dr. Casey Peavler","html":"","width":"100%","height":180,"duration":4033,"description":"What if cancer is better understood as a metabolic and mitochondrial disease than a purely genetic one? In this episode, Dr. Ravi Kumar talks with a hospitalist who has spent years digging into the metabolic science of cancer about the idea that mitochondrial dysfunction may actually come first, as a precursor to the genetic abnormalities we associate with tumors, and what that reframing opens up for patients already in treatment.\nDoctor Peavler is a hospitalist by day who began offering integrative consults to cancer patients a little less than two years ago. He was a flight surgeon in the Air Force, where he took hyperbaric medicine courses, and he now runs a science-heavy YouTube channel with over 200 long-form videos. He takes consults from people all over the world and is upfront that he loses many of them to follow-up, which means he can't claim outcomes data the way a formal trial could.\nThe two dig into the press-pulse framework: a chronic \"press,\" like a therapeutic ketogenic diet paired with mind-body stress reduction, meant to lower glucose, insulin, glucocorticoids and catecholamines over time, combined with intermittent \"pulses\" delivered when a tumor is already weakened. The logic rests on a quirk of cancer biology. Normal cells with healthy mitochondria and enough oxygen can switch fuels as needed, but cancer cells with damaged mitochondria and hypoxia are stuck relying on glucose and glutamine, the same two fuels that supply most of the NADPH a cell needs to defend itself against oxidative stress.\nOn the pulse side, they cover high dose IV vitamin C, which works less as an antioxidant and more as a pro-oxidant that reacts with extracellular iron to generate free radicals inside iron-hungry tumor cells, and hyperbaric oxygen, which dissolves oxygen into plasma rather than just topping off hemoglobin, letting it reach the hypoxic pockets a tumor's leaky vessels can't. They also get into repurposed drugs like metformin, mebendazole, and ivermectin,...","thumbnail_url":"https://img.transistorcdn.com/1b0HAhl7LyS1JMvttJBUPVo13Xhw89dNIYFNVWa7Un0/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS83NGVi/ODc5ZmE2MTI0Njdj/NWRjODE2NTkzNTQ0/ZjY0Yi5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}