{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-肿瘤学","title":"今日肿瘤学最高分文献 - 2025-09-23","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/7a3e577b\"></iframe>","width":"100%","height":180,"duration":188,"description":"科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。\n\n本期关注发表在《Journal of the American Geriatrics Society》(IF: 4.3)上的重要研究\"Age of Patients in Trials Submitted to the FDA Versus Age in Average Patients With Cancer\"。这项研究发现，癌症临床试验参与者与实际患者间存在持续5年的年龄差距—临床试验中位年龄为62岁，而实际患者为67岁。尽管FDA已发布指导方针鼓励纳入更多老年患者，研究显示年龄差距虽从2002-2012年的7年缩小至2020-2024年的4年，但仍显著存在。这种代表性不足限制了我们对治疗在老年群体中安全性和有效性的理解，强调了通过监管监督加强临床试验参与者多样性的紧迫性。","thumbnail_url":"https://img.transistorcdn.com/3WX36CzvFOrNjlF7WfWjzS4HdcMIMmzMs2bmPS-ejLU/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS83NDNm/MjQ1N2E5NjhjMzVj/NjM0ZTA3YzY2NDE2/ZmIyMi5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}