{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Impactful Breakthroughs","title":"Jennifer Good - President & CEO, Trevi Therapeutics","html":"","width":"100%","height":180,"duration":2153,"description":"When all of the experts around you say it’s impossible to move the needle forward, how do you still maintain commitment to your research and patients? On the very first episode of Impactful Breakthroughs, Zach Gobst is joined by Jennifer Good, the President & CEO of Trevi Therapeutics, to explore why she has dedicated the past fifteen years to tackling one of medicine’s most overlooked conditions: chronic cough.\n\nJennifer traces her path from running Pennwest Pharmaceuticals to negotiating a promising compound out of an acquisition and building Trevi from her kitchen table into the $2B public company it is today. She shares how a background in chronic pain research gave her and Co-Founder Dr. Thomas Sciascia a uniquely brain-centered lens on cough, and why listening closely to patients led them to double down on IPF when key opinion leaders told them to walk away. Equal parts science story and entrepreneurial journey, this conversation is a candid look at what perseverance, patient focus, and the willingness to evolve really look like in biotech.\n\nTimestamps\n\n00:00 Episode Start\n03:00 Starting Trevi Therapeutics from the kitchen table\n05:45 Advice for early entrepreneurs\n07:30 Setting checkpoints and sticking to them\n08:45 What was missing on chronic cough and IPF\n12:45 How chronic pain research unlocked a new view of cough\n18:45 Where Trevi fits into the patient experience\n22:45 Reflections on her 15-year journey\n25:30 Evolving the team as the company grows\n32:00 Giving back through rare disease boards and community\n34:45 Mentorship shoutouts\n\nKey Takeaways\nThe brain matters in cough. While the broader industry was targeting peripheral receptors in the lung, Trevi's neurology-rooted perspective led them to the brain, setting their data apart when everything else failed.\nStay close to the patient. Jennifer's most powerful moment came from a patient advisory board member who couldn't finish her grocery shopping because of a coughing attack. That story is what...","thumbnail_url":"https://img.transistorcdn.com/uUl5NjCb9mY4i46LGv4GWJrr5WVj3WxuYTgjBphYmcc/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS85MDM0/ZDk5OWI2YTcwYWRh/NTM0NzIyODViMjU4/ODlmZS5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}