{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"HemeTalks: Conversations in Hematology Education","title":"Relapsed Myeloma: Navigating Post-BCMA Therapy Failure ","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/7f6d3137\"></iframe>","width":"100%","height":180,"duration":1366,"description":"Join us for an insightful discussion with Drs. Natalia Neparidze and Saad Z. Usmani as we explore treatment strategies for relapsed multiple myeloma following BCMA-targeted therapy failure. With CAR T-cell therapy and bispecific antibodies revolutionizing myeloma treatment, clinicians are now faced with new challenges as patients relapse after BCMA-directed therapies. Through the case of a 62-year-old woman who relapsed one year post-BCMA CAR T-cell therapy, we will discuss mechanisms of resistance, treatment sequencing, and the role of novel agents like selinexor-pomalidomide-dexamethasone. This episode will provide hematologists with practical strategies to navigate post-BCMA treatment failure and optimize patient outcomes.  Learning Objectives Understand mechanisms of resistance and progression following BCMA-targeted therapy.  Explore non-BCMA treatment options, including alternative targets and novel agents.  Recognize key factors influencing treatment selection and patient management. ","thumbnail_url":"https://img.transistorcdn.com/M5rGPmC9Sw2Vy8WK-H0ZSbRLaRVoK-0Omj9mAqmEk0Q/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS80ZWE4/ZTc4YTNmNGExOGYw/ZmIyNGJjNWEyMWE4/YmYyMi5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}