{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-11-30","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/814dc004\"></iframe>","width":"100%","height":180,"duration":206,"description":"科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Nucleic acids research》(IF:16.6)上的重要研究\"PolyA_DB v4: systematic polyA site identification and isoform annotation in human and mouse genomes using 3' end and long-read sequencing data\"。这项研究更新了哺乳动物基因组中多聚腺苷酸化位点(PAS)的数据库，通过分析海量转录组数据，在人类和小鼠基因组中各识别约140万个PAS，覆盖度比上一版本提高了4.9倍和3.5倍。研究还发现长读测序技术能有效补充传统方法，约20%的PAS与长读测序数据匹配，为RNA末端注释提供了更精确的图谱。这一数据库对理解基因表达调控、RNA剪接机制及开发靶向RNA的治疗策略具有重要意义。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}