{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Thinking In Psychiatry","title":"Did Ketamine 'Fail' or Are We Asking The Wrong Questions? *Full Study Review*","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/88b46a65\"></iframe>","width":"100%","height":180,"duration":937,"description":"Access mentioned courses here:\nClinical Audit On Cognitive Aspects of Depression: \nhttps://psychscene.co/3Z2EdvH\nThe Aggregation of Marginal Gains as a Philosophy of Clinical Care with Prof Michael Berk: \nhttps://psychscene.co/4rqS62V\nIn this episode, Dr Sanil Rege examines the KARMA-Dep 2 trial, a randomised controlled trial comparing adjunctive serial ketamine infusions to midazolam for patients with Treatment-Resistant Depression (TRD) in an inpatient setting.\nBased on a JAMA Psychiatry article titled “Serial Ketamine Infusions as Adjunctive Therapy to Inpatient Care for Depression,” the discussion explores why statistically insignificant differences between ketamine and psychoactive comparators necessitate a shift in how clinicians evaluate rapid-acting antidepressants, detailing the \"wow effect\" of early symptomatic drops and the subsequent plateauing of recovery curves.\nThis podcast provides clinicians with a clinical framework for differentiating between acute symptomatic response and long-term functional recovery in TRD.\nChapters:\n00:22 - The KARMA-Dep 2 Trial Headlines \n03:44 - Primary Outcomes: Ketamine vs. Midazolam Results\n04:26 - Analysing the Curves: The \"Wow Effect\" vs. Sustained Recovery\n08:50 - Neurobiology of Response vs. Neurobiology of Recovery\n09:21 - Why Improvement Stalls: The Role of Neuroadaptation\n10:47 - Clinical Implications for Inpatient Care\nTo get access to more materials like this plus over 150 hours of interactive CPD education on psychiatry, check out The Academy using the link below:\nhttps://psychscene.co/4rl6pFV","thumbnail_url":"https://img.transistorcdn.com/Lw4BM23swTaSGSQDTeu0xzNWxYaebSgRjmLxoDtrgeI/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS80ODdl/Zjc0NjU1ZmNhZjVi/ZWFiMmQ2NDg1YjVi/NzI4NC5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}