{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Blood Cancer Talks","title":"Episode 19. Management of Primary Myelofibrosis","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/88d56531\"></iframe>","width":"100%","height":180,"duration":3556,"description":"In this episode, we discuss the diagnosis and management of primary myelofibrosis with Dr. Ayalew Tefferi at Mayo Clinic, Rochester, Minnesota. Here are the show notes, including key studies discussed in this episode:\n1. Risk stratification of PMF:\nMIPSS70 Score: http://www.mipss70score.it\nhttps://ascopubs.org/doi/full/10.1200/JCO.2017.76.4886\nGenetically inspired prognostic scoring system (GIPSS):\nhttps://www.nature.com/articles/s41375-018-0107-z\nType 1 CALR mutation:\nhttps://ashpublications.org/blood/article/124/15/2465/33454\nMYSEC-PM:\nhttp://www.mysec-pm.eu\nhttps://www.nature.com/articles/leu2017169\n2. Treatment of PMF with JAK inhibitors \nhttps://pubmed.ncbi.nlm.nih.gov/36680511/\nMomelotinib:\nhttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02036-0/fulltext\nPacritinib : https://ashpublications.org/blood/article/140/Supplement%201/1518/490663\nhttps://jamanetwork.com/journals/jamaoncology/fullarticle/2674384\nFedratinib:\nhttps://onlinelibrary.wiley.com/doi/10.1111/bjh.18284\n3. Allogeneic Transplant in PMF\nhttps://ashpublications.org/hematology/article/2021/1/453/482995\nBlack African-American patients with primary myelofibrosis\nhttps://ashpublications.org/bloodadvances/article/doi/10.1182/bloodadvances.2022009611/494460\n4. Imtelestat in PMF\nhttps://www.nejm.org/doi/full/10.1056/NEJMoa1310523","thumbnail_url":"https://img.transistorcdn.com/sqlYzk0Oxhchi1Lmft_9Md8dG97D7hyy2rwRG7COuc0/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9zaG93/LzMyMDc4LzE2NTcz/MTQxMDUtYXJ0d29y/ay5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}