{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-肿瘤学","title":"今日肿瘤学最高分文献 - 2024-11-08","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/92c04111\"></iframe>","width":"100%","height":180,"duration":4,"description":"欢迎收听医学新发现！今天，我们要探讨的是Nature杂志的一项突破性研究，揭示了癌细胞中的额外染色体DNA（ecDNA）与治疗抵抗和预后不良的关系。研究分析了近15000名患者的近40种肿瘤样本，发现17.1%的样本含有ecDNA。这些ecDNA不仅放大了致癌基因，还经常放大调节免疫反应的基因，导致肿瘤T细胞浸润减少。这项研究不仅揭示了ecDNA的临床重要性，还为癌症治疗提供了新的视角。不要错过这一突破性的医学进展！","thumbnail_url":"https://img.transistorcdn.com/3WX36CzvFOrNjlF7WfWjzS4HdcMIMmzMs2bmPS-ejLU/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS83NDNm/MjQ1N2E5NjhjMzVj/NjM0ZTA3YzY2NDE2/ZmIyMi5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}