{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Trial Talk","title":"Episode 3: Subgroup analysis - Who benefits most from a treatment?","html":"","width":"100%","height":180,"duration":1725,"description":"Clinical trial results usually tell us how effective a treatment was on average for the overall group of participants, but a key question for clinicians, patients and policy makers is: which individual patients benefit most from the treatment and which don’t benefit as much? In the latest episode of the Trial Talk podcast, Peter Godolphin and David Fisher discuss a new method for determining how treatment effects differ between subgroups of patients across multiple clinical trials, as well as how other meta-analysis researchers can use it.\nResources:\n• Estimating interactions and subgroup-specific treatment effects in meta-analysis without aggregation bias: A within-trial framework onlinelibrary.wiley.com/doi/10.1002/jrsm.1590\n• Cochrane webinar recording training.cochrane.org/resource/estim…-meta-analysis\n• GitHub page for metafloat package in Stata github.com/UCL/metafloat\n• WHO REACT Group: IL6 Prospective meta-analysis jamanetwork.com/journals/jama/fullarticle/2781880\n• STOPCAP collaborators: Docetaxel IPD meta-analysis www.thelancet.com/journals/lanonc/…00230-9/fulltext\nFor questions about the within-trial framework for subgroup analysis, you can email d.fisher@ucl.ac.uk or p.godolphin@ucl.ac.uk.\nFor more information and to access the transcript: bit.ly/43boETF\nFor questions or feedback on the podcast series, message us at mrcctu.engage@ucl.ac.uk \nAs a listener, your opinion is very valuable to us. Please help us to improve the podcast in the future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g\n Date of episode recording: 2024-03-12T00:00:00Z\n Duration: 00:28:44\n Language of episode: English\n Presenter: Charlotte Hartley\n Guests: Peter Godolphin, David Fisher\n Producer: Charlotte Hartley\n ","thumbnail_url":"https://img.transistorcdn.com/_Gs61f_CYn4elE1E_qmem3ay3JqZHcF-BnvFPSYiuWI/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8wNjkz/NGQyMDRlMjRkNDcw/MGU1MTNiN2I4NDkw/MTYzYi5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}