{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-11-29","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/9aa115e6\"></iframe>","width":"100%","height":180,"duration":206,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。\n\n本期关注发表在影响因子高达26.8的《Journal of hepatology》上的重要研究：\"Maladaptive emergency granulopoiesis predicts poor outcomes in patients hospitalized with decompensated cirrhosis.\"这项研究揭示了肝硬化急性失代偿患者发展为肝衰竭的关键机制。研究通过分析1260名患者的全血转录组数据，发现适应性不良的紧急粒细胞性生成(EG)可预测患者28天内发展为急性慢性肝衰竭(ACLF)的高风险。这些患者表现出中性粒细胞增多、STAT3-CEBPB轴激活以及免疫抑制性粒细胞增多等特征。这一突破性发现不仅阐明了ACLF发展的病理机制，还为开发针对性生物疗法和早期预测生物标志物提供了新方向，有望显著改善肝硬化患者的临床管理。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}