{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-11-16","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/a05f03ac\"></iframe>","width":"100%","height":180,"duration":201,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Aging cell》(IF:8.0)上的重要研究\"Enhancer Rewiring Orchestrates Inflammation and Loss of Cell Identity During Muscle Stem Cell Aging\"。研究发现，肌肉干细胞衰老过程中存在渐进性分子变化：早期出现促炎信号增强和细胞身份丧失，后期则表现为炎症加剧、增强子广泛激活和3D基因组重编程。这些变化与干扰素信号、内源性逆转录病毒表达和NFκB活性密切相关，最终导致肌肉组织退化、成肌能力丧失。这一发现为理解肌肉衰老机制提供了新视角，也为开发针对肌肉退行性疾病的干预策略提供了潜在靶点。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}