{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2026-03-22","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/a1bb959a\"></iframe>","width":"100%","height":180,"duration":157,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期我们关注发表在Cell（影响因子45.5）上的重要研究\"The E3-ome gene-centric compendium reveals the human E3 ligase landscape\"。这项研究创建了人类E3泛素连接酶的完整目录，揭示了672个高置信度E3s，并建立了统一的分类框架。研究不仅发现了多个新的E3结构域和候选物，还绘制了E3在不同组织和细胞类型中的分布图谱，揭示了其组织特异性表达模式。更令人兴奋的是，研究将E3变异与多种人类疾病联系起来，为靶向E3的治疗策略提供了重要基础。这项工作为理解蛋白质降解机制和开发新型疾病治疗方法开辟了新途径。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}