{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Hard Drugs","title":"Lenacapavir: The miracle drug that could end AIDS","html":"","width":"100%","height":180,"duration":17626,"description":"Lenacapavir is a new HIV drug that blocks infections with an efficacy rate of nearly 100%, and it could completely change the fight against HIV worldwide. Saloni and Jacob talk about the development and prospects for this new drug, as well as the history of HIV, the initial discovery of retroviruses, and how HIV was transformed from a death sentence to a manageable condition.\nHard Drugs is a new podcast from Works in Progress and Open Philanthropy about medical innovation presented by Saloni Dattani and Jacob Trefethen.\nChapters:\n00:00 Intro\n03:52 How was HIV discovered? Where did it come from, and how does it attack the body and cause AIDS?\n38:10 Antiretrovirals: How did scientists develop breakthrough HIV drugs — from azidothymidine to protease inhibitors to PrEP?\n1:51:35 How does prevention and treatment work today?\n2:19:03 HIV’s capsid and the breakthrough of lenacapavir, the first-approved HIV capsid inhibitor\n2:50:36 How to develop long-lasting treatments\n3:14:45 Lenacapavir’s near 100% efficacy in clinical trials\n3:48:40 The impact of global programs against HIV, and can we now end HIV?\nSaloni’s substack newsletter: https://www.scientificdiscovery.dev/\n\nJacob’s blog: https://blog.jacobtrefethen.com/ \n\nBooks:\nHow to Survive a Plague — by David France (2016). [Mentioned as a history of the science and activism against the AIDS epidemic, and the protease-inhibitor breakthrough.] https://surviveaplague.com/ \nAnd the Band Played On — Randy Shilts (1987). [Mentioned as an account of the early years of AIDS.] https://us.macmillan.com/books/9780312374631/andthebandplayedon/ \nDrug development stories: From bench to bedside — Elsevier (2024). [Mentioned as containing a history of the development of lenacapavir] https://shop.elsevier.com/books/drug-discovery-stories/yu/978-0-443-23932-8 \nRetrospectives:\nThe development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic — Samuel Broder (2015). https://doi.org/10.1016/j.antiviral.2009.10.002 \nHistory...","thumbnail_url":"https://img.transistorcdn.com/bBbAA3-An3hw3uv_Sf647ZQV-IpESOooEROiyEp4Ytg/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS81MzM2/YTc5NmRlZGI2Zjhi/YWM2ZDk4MzBhZjg4/YTRjMi5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}