{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2026-03-04","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/aee9c55d\"></iframe>","width":"100%","height":180,"duration":211,"description":"科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。\n\n本期关注发表在《Nucleic acids research》(IF:16.6)上的重要研究\"Caffeine inhibits nonhomologous end joining by impairing ligase IV/XRCC4 function\"。这项突破性发现揭示了咖啡因不仅抑制同源重组，还直接干扰DNA双链断裂的非同源末端连接(NHEJ)修复机制。研究显示咖啡因结合XRCC4蛋白，破坏其与DNA连接酶IV的相互作用，导致DNA断裂积累和细胞存活率下降。这一发现不仅阐明了咖啡因影响DNA修复的新机制，还可能对癌症治疗策略产生重要影响，特别是针对依赖NHEJ修复的肿瘤细胞。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}