{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-11-01","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/b5738ba9\"></iframe>","width":"100%","height":180,"duration":216,"description":"科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在影响因子9.1的《British Journal of Anaesthesia》上的研究\"Integrated 3D human cerebral organoids and paediatric patient serum analysis reveals mechanisms and biomarkers of anaesthetic-induced neurotoxicity\"。这项创新研究结合了人类大脑类器官和儿童患者血清分析，揭示了麻醉剂诱导神经毒性的新机制。研究发现丙泊酚暴露会导致细胞凋亡增加、自噬激活，并影响553个mRNA和792个lncRNA的表达，这些基因与突触功能和线粒体活性密切相关。更令人关注的是，研究确定了CKMT1B等可作为生物标志物的分子，为临床监测麻醉安全性提供了新工具，对儿童麻醉实践具有重要意义。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}