{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Talking Biotech with Dr. Kevin Folta","title":"A Gene-Edited Vaccine Against Malaria - Dr. Stefan Kappe","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/b7b7d49a\"></iframe>","width":"100%","height":180,"duration":2320,"description":"Malaria is a deadly, mosquito-vectored disease in areas of the Developing World. Intensive efforts have resulted in few effective prophylactic or therapeutic practices or products that are without serious limitations. A vaccine against the causative organism would be ideal, but even vaccine strategies have drawbacks. Dr. Stefan Kappe and his team have devised a new vaccine strategy based on attenuation of the plasmodium parasite, using genetic engineering. CRISPR/Cas9 has been used to alter genes associated with life cycle and development, conferring immunological response to a complex set of antigens. Trials suggest good protection and safety from this strategy. ","thumbnail_url":"https://img.transistorcdn.com/_MuYymHB8DyD_ilSNWvM5e3m1cLacc52bP7TjNaiLRE/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9jZjJk/YjMwNDM2ZTY2NDJi/ZDczYzEwZmFkODUy/YWIyMi5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}