{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Peri & Pause The Podcast","title":"Progesterone 101","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/bad65050\"></iframe>","width":"100%","height":180,"duration":656,"description":"Jamie Gallagher, a board-certified family nurse practitioner and Menopause Society certified practitioner, explains progesterone’s roles beyond pregnancy and what happens as it declines during perimenopause. She describes progesterone as a calming, balancing hormone with receptors in the brain, uterus, breast tissue, and bone, noting its conversion to allopregnanolone and its effects on sleep, anxiety, irritability, and mood. She explains how falling progesterone—often before estrogen—can create “estrogen dominance,” contributing to heavy or irregular periods and intensified PMS/PMDD-like symptoms, and notes that micronized progesterone (Prometrium) may help in early perimenopause. She also clarifies progesterone vs synthetic progestins (e.g., MPA/Provera), highlighting that the Women’s Health Initiative used a progestin, not micronized progesterone, and that these differences matter when interpreting hormone therapy risks and benefits.\n00:00 Welcome and Recap\n00:48 Progesterone Beyond Pregnancy\n01:40 Calming Hormone Balance\n02:43 Brain Sleep and Anxiety\n03:27 Uterus Period Changes\n04:14 Breast Bone and Mood\n05:30 Perimenopause Symptom Timeline\n07:28 Progesterone vs Progestins\n09:45 Wrap Up and Disclaimer","thumbnail_url":"https://img.transistorcdn.com/blIqoXV8cJEwQkLxFiT2hhmzV5NFQ3SQUL8ePL6tRgE/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8wMGVj/M2RkYjA1MGExODEw/MzY2Mjk3NzUwODE5/MmNmNi5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}